CRISPR Breakthrough: Scientists Repair Mutation in Human Embryos

I know religious folks do not believe in science like this — because MUH embryos. As much as I’d like to tar and feather many in the science field, I cannot permit any of you to spew hatred for modern medicine of this magnitude.

The first known attempt at creating genetically modified human embryos in the United States has been carried out by a team of researchers in Portland, Oregon, MIT Technology Review has learned.

The effort, led by Shoukhrat Mitalipov of Oregon Health and Science University, involved changing the DNA of a large number of one-cell embryos with the gene-editing technique CRISPR, according to people familiar with the scientific results.

Until now, American scientists have watched with a combination of awe, envy, and some alarm as scientists elsewhere were first to explore the controversial practice. To date, three previous reports of editing human embryos were all published by scientists in China.

Now Mitalipov is believed to have broken new ground both in the number of embryos experimented upon and by demonstrating that it is possible to safely and efficiently correct defective genes that cause inherited diseases.

What does this mean for ordinary faggots, such as yourselves?

You won’t get aids anymore.

What is the bigger picture here?

Eugenics on a demonstrable scale that only Hitler could be smile upon.

Rich folk will be able to ‘edit’ the genes of their babies to create a master race of highly athletic, intelligent, super-humans, while the rest of you play baby-lottery — hoping to create a life able to compete in a new world of advanced science.

The report also offered qualified support for the use of CRISPR for making gene-edited babies, but only if it were deployed for the elimination of serious diseases.

The advisory committee drew a red line at genetic enhancements—like higher intelligence. “Genome editing to enhance traits or abilities beyond ordinary health raises concerns about whether the benefits can outweigh the risks, and about fairness if available only to some people,” said Alta Charo, co-chair of the NAS’s study committee and professor of law and bioethics at the University of Wisconsin–Madison.

Stocks with CRSPR exposure include EDIT, CRSP, JUNO, NTLA, VRTX, REGN, CELG, SGMO, ABEO. I’m sure there are others.

If you’ve been buying 3D printer stocks because ‘they are the future’, you should be physically removed from society. These are bad companies, with stupid premises.

Do you remember when DDD was going up for no good reason?

Yeah, well now its going down for a damned good one — their business sucks.

Reports Q2 (Jun) earnings of $0.08 per share, excluding non-recurring items, $0.04 worse than the Capital IQ Consensus of $0.12; revenues rose 0.9% year/year to $159.47 mln vs the $163.01 mln Capital IQ Consensus.

Co issues guidance for FY17, sees EPS of approx $0.46, excluding non-recurring items, vs. $0.51 Capital IQ Consensus Estimate and vs prior guidance of $0.51-0.55; sees FY17 revs of $643-671 mln vs. $660.69 mln Capital IQ Consensus Estimate.

Most analysts are milquetoast on the stock, except the gigantic faggot at FBR — who reiterated his ‘market perform.’

FBR reiterates Market Perform. The firm notes the second quarter was negatively affected by challenged execution in professional printers that could, in the firm’s view, continue to negatively affect performance in that region, near term. On balance, the firm expects that shares will largely be in a holding pattern, near term, awaiting an analyst conference that management has telegraphed as occurring in September, which could allow management to lay out its long-term vision for DDD’s next steps.

Needham stays at Hold. The firm believes, while DDD is seeing solid growth in the healthcare vertical, software, and production printing, conditions remain challenging in the professional 3D printing (prototyping) market.

Stifel stays at Hold; tgt of 15. The firm notes demand for production printers was highlighted as being strong, with main issue in the quarter related to execution with professional printers.

There’s nothing else to discuss here. The stock is finished and the sector will need recover.

Holy shit, whoever leaked this to WaPo is a gigantic faggot. There is so much betrayal taking place inside the White House, Trump would be better served never working from that cesspool again.

When the President first took office, the media ran some reports, based upon leaks of Trump’s conversations with the Mexican and Australian leaders. Six months removed from that, the cucks at WaPo have published the entire transcripts of those conversations.

The ‘journalists’ at the Washington Post are giant shitstains on the integrity of the press in America. These transcripts do not tell us anything unusual or something un-Trump like. If anything, they confirm the fact that Trump was serious about the wall and not accepting refugees from savage countries. But what these transcripts do prove is the willingness of the ‘free press’ to do anything they can, within their power, to undermine the administration. Moreover, it proves that Trump cannot trust any of those fucking ‘notetakers’, who were recently excluded from Trump’s talks with Putin, which received an acrimonious response from all of the neocon and leftists filth in the press and on the political side of the sewer.

Here is WaPo’s background on the transcripts, describing how they were recorded.

The transcripts were based on records kept by White House notetakers who monitored Trump’s calls. Known as a “memorandum of conversation,” such documents are commonly circulated to White House staff and senior policymakers.

Both documents obtained by The Post contain notes indicating they were reviewed and classified by retired Lt. Gen. Keith Kellogg Jr., who serves as chief of staff on the National Security Council.

And here are the highlights.

But in his first White House call with Mexico’s president, Trump described his vow to charge Mexico as a growing political problem, pressuring the Mexican leader to stop saying publicly that his government would never pay.

“You cannot say that to the press,” Trump said repeatedly, according to a transcript of the Jan. 27 call obtained by The Washington Post. Trump made clear that he realized the funding would have to come from other sources but threatened to cut off contact if Mexican President Enrique Peña Nieto continued to make defiant statements.

The funding “will work out in the formula somehow,” Trump said, adding later that “it will come out in the wash, and that is okay.” But “if you are going to say that Mexico is not going to pay for the wall, then I do not want to meet with you guys anymore because I cannot live with that.”

He described the wall as “the least important thing we are talking about, but politically this might be the most important.”

The Jan. 28 call with Turnbull became particularly acrimonious. “I have had it,” Trump erupted after the two argued about an agreement on refugees. “I have been making these calls all day, and this is the most unpleasant call all day.”

Before ending the call, Trump noted that at least one of his conversations that day had gone far more smoothly. “Putin was a pleasant call,” Trump said, referring to Russian President Vladi­mir Putin. “This is ridiculous.”

“This is going to kill me,” he said to Turnbull. “I am the world’s greatest person that does not want to let people into the country. And now I am agreeing to take 2,000 people.”

“On the wall, you and I both have a political problem,” Trump said. “My people stand up and say, ‘Mexico will pay for the wall,’ and your people probably say something in a similar but slightly different language.”

Trump seemed to acknowledge that his threats to make Mexico pay had left him cornered politically. “I have to have Mexico pay for the wall — I have to,” he said. “I have been talking about it for a two-year period.”

To solve that problem, Trump pressured Peña Nieto to suppress the issue. When pressed on who would pay for the wall, “We should both say, ‘We will work it out.’ It will work out in the formula somehow,” Trump said. “As opposed to you saying, ‘We will not pay,’ and me saying, ‘We will not pay.’ ”

Peña Nieto resisted, saying that Trump’s repeated threats had placed “a very big mark on our back, Mr. President.” He warned that “my position has been and will continue to be very firm, saying that Mexico cannot pay for the wall.”

Trump objected: “But you cannot say that to the press. The press is going to go with that, and I cannot live with that.”

Searching for an exit, Peña Nieto reiterated that the border plan “is an issue related to the dignity of Mexico and goes to the national pride of my country” but agreed to “stop talking about the wall.”

“We have a massive drug problem where kids are becoming addicted to drugs because the drugs are being sold for less money than candy,” Trump said. “I won New Hampshire because New Hampshire is a drug-infested den.”

He described Mexican drug cartel leaders as “pretty tough hombres” and promised U.S. military support, saying that “maybe your military is afraid of them, but our military is not.”

Peña Nieto responded by saying that drug trafficking in Mexico is “largely supported by the illegal amounts of money and weapons coming from the United States.”

Despite the friction, Trump at other moments sought to sweet-talk Peña Nieto, telling him that “you and I will always be friends,” and that if they could resolve their disputes over the border and trade, “We will almost become the fathers of our country — almost, not quite, okay?”

At one point, Trump expressed admiration for Australia’s refusal to allow refugees arriving on boats to reach its shores, saying it “is a good idea. We should do that too.” In a remark apparently meant as a compliment, Trump told Turnbull, “You are worse than I am.”

But the conversation rapidly deteriorated.

“I hate taking these people,” Trump said. “I guarantee you they are bad. That is why they are in prison right now. They are not going to be wonderful people who go on to work for the local milk people” — an apparent reference to U.S. dairy farms.

Turnbull tried to salvage the deal, noting that the detainees were economic refugees who had not been accused of crimes. He explained that they were being denied entry into Australia because of a policy aimed at discouraging human smuggling.

“There is nothing more important in business or politics than a deal is a deal,” Turnbull said. “You can certainly say that it was not a deal that you would have done, but you are going to stick with it.”

Trump only became angrier, saying the refugees could “become the Boston bomber in five years.”

“I think it is a horrible deal, a disgusting deal that I would have never made,” Trump said. “As far as I am concerned, that is enough, Malcolm. I have had it.”

Turnbull tried to turn to Syria and other subjects. But Trump refused. The call, which began at 5:05 p.m., ended 24 minutes later with Turnbull thanking the still-fuming Trump for his commitment.

“You can count on me,” Turnbull said. “I will be there again and again.”

“I hope so,” Trump said before saying thank you and hanging up.

Like I said, GIGANTIC fucking faggots.

The research monkeys at Goldman were tasked with the duty of combing over 10-ks to find which companies domiciled in the US had the most international exposure. If they left before midnight, someone was stationed outside the offices to throw hot coffee on their necks, as a medieval form of punishment for working lazily.

The theory here is to buy companies who collect revenues in non-dollars, because they’re going up, which will then translate into higher profits once the money is brought back into the United States to report quarterly earnings. Bookmark this post, for it will become useful when the dollar starts to soar again and you’re looking for stocks to sell short.

Goldman summarizes.

Foreign sales accounted for 29% of aggregate revenue for the S&P 500 in 2016.The
median stock reported 27% of sales outside the US. Both of these figures are similar
to those in 2015. Companies reported that 10% of revenues came from EMEA (Europe,
Middle East, and Africa), with 6% directly attributable to Europe. Approximately 8% of
revenues stemmed from the Asia Pacific region with 1% disclosed as coming
specifically from Japan and 2% from China. Roughly 7% of revenues were foreign but
unclassifiable.

We analyzed company 10-K filings to determine the geographic revenue exposure
of stocks in the S&P 500. The Financial Accounting Standards Board (FASB) requires
companies to disclose any geographic segment contributing 10% or more of sales.
Firms have discretion over regional classifications, so precision varies by company and
analysis excludes some foreign revenues that are not divulged due to this limit. We
supplement exposure disclosed in 10-K filings using company presentations and
Goldman Sachs analyst estimates.

Our analysis includes the revenues of all S&P 500 companies, including those with
purely domestic sales. Statistics regarding S&P 500 geographical exposures are
frequently cited based only on companies that report international exposure. As
explained above, firms must report geographic segments accounting for at least 10% of
sales, and many firms even report exposures totaling less than 10%. However, many
S&P 500 firms sell only to customers in the United States. For example, in our data
more than 100 companies have zero international exposure. Excluding these companies
results in an overstatement of foreign exposure for the aggregate S&P 500 index.

And here is the fruits of their labor.

This is the breakdown, per sector.

Year to date, these companies have crushed domestic oriented companies. Whether this trend can continue, I leave up to you to decide.

Good morning lads. I’m at the dealership this morning, getting ripped off on some brake pads and tires.

The President of the United States has spoken this morning, via Twitter, blaming the cucks in Congress for ruining our relationship with Russia. Moreover, the President is taking ownership of the stock market rally.

Is this a good idea, based upon historical tomfoolery in the market?

Our relationship with Russia is at an all-time & very dangerous low. You can thank Congress, the same people that can't even give us HCare!

— Donald J. Trump (@realDonaldTrump) August 3, 2017

Business is looking better than ever with business enthusiasm at record levels. Stock Market at an all-time high. That doesn't just happen!

— Donald J. Trump (@realDonaldTrump) August 3, 2017

In a CNN exclusive, Chris Cuomo said Anthony Scaramucci will hold a Facebook live event on Friday, in order to defend his honor. According to Cuomo, The Mooch feels the media has unfairly maligned him and he wants to set the record straight.

In regards to his brief term at the White House, he says it was a success — comparing himself to a ‘special purpose vehicle’ (SPV) whose sole purpose was to clear the decks and vanquish the west wing of leakers and “disrupt the culture of leaking and counterproductive infighting”. Aside from Steve Bannon still sucking his own cock inside the White House, Scaramucci considers his time with Trump a success.

Huffington Post had some color on the events that led up to Scaramucci’s departure.

As soon as Scaramucci returned from Wednesday night’s dinner, he called Lizza and gave his now-infamous interview, published Thursday, in which he suggested that former White House Chief of Staff Reince Priebus was a “paranoid schizophrenic” and that White House chief strategist Steve Bannon practiced auto-fellatio.

Scaramucci said he felt burned by the interview. “The Lizzas and Scaramuccis have been friends for over 50 years. My dad knew his dad from construction, and we were building a personal relationship. Most of what I said was humorous and joking. Legally, it may have been on the record, but the spirit of it was off. And he knew that.”

Still, Scaramucci told me, he has plans to take Lizza out for a beer.

When I asked Lizza for his response, he wrote back: “I’ve only known Anthony in his capacity as a Trump surrogate and then White House communications director. We are not and have never been ‘old family friends,’ though I think our fathers knew each other, so maybe that’s what he’s talking about. (The Long Island Italian world in that generation is relatively small.) But again, that would not be a reason to suppress an explosive on-the-record interview.”

But on Monday morning, Scaramucci knew he was cooked. Retired Marine Gen. John Kelly, the new chief of staff, who insisted that all White House staff report to him, asked for his resignation. “It was a very polite conversation,” Scaramucci says.

Scaramucci then went to see Trump, who was unavailable. He ended up speaking with the president, his daughter Ivanka Trump and his son-in-law, Jared Kushner, separately later in the day by telephone. All were gracious, he said. “The president told me he knows I have his back, but he has to try to tighten the ship.”

So what are you going to do next, I asked him.

“I am now going to go dark,” he said.

And then?

“Then I will reemerge.” He paused. “As me.”

SAD!

Stephen Miller destroyed two reporters today, who may not recover. His first victim was the NY Times Glenn Thrush. The second, and most severely battered, was CNN’s Jim Acosta — who accused Trump’s new English requirement for immigrants as a racist policy meant to import gents from Great Britain and Australia.

The result of his comments was a furious and energetic verbal thrashing, calling out Jim for having a shockingly ignorant ‘cosmopolitan bias’. This is one for the ages.

Cosmopolitan Jim Acosta and his chic friend, Huma Abedin

Enjoy.

Short version

CNN's Jim acosta has been destroyed by Stephen Miller for being an ignorant cosmopolitan pic.twitter.com/RbFzvBBqJY

— The_Real_Fly (@The_Real_Fly) August 2, 2017

Full version

The Chief White House correspondent for the NY Times, Glenn Thrush, was utterly and vigorously humiliated today — by Trump’s senior policy advisor, Steven Miller.

NY Times Chief White House Correspondent, Glenn Thrush, lost his hat today

‘Maybe it’s time we had compassion for American workers, Glenn.’

This was a vicious beatdown. Glenn Thrush should resign from his post and live out the rest of his days tending to transgender goats in the green fields of Romania.

KLIC makes gold wire bonding for semiconductors and is considered to be a forward looking indicator for the entire sector. I don’t have time to dig through old articles now, but trust me when I tell you this isn’t the first time a KLIC shortfall brought down the entire semiconductor space. I recalls several years ago, maybe 2010 or 2011, a warning out of KLIC caused a full fucking chimp out in the tech sector.

More or less, we’re getting some weakness today thanks to both KLIC and MTSI earnings disappointments.

KLIC

Reports Q3 (Jun) earnings of $0.62 per share, excluding non-recurring items, $0.06 worse than the Capital IQ Consensus of $0.68; revenues rose 12.7% year/year to $243.9 mln vs the $245.02 mln Capital IQ Consensus.
Gross margin of 45.8%.

Co issues upside guidance for Q4, sees Q4 revs of $200-215 mln vs. $193.60 mln Capital IQ Consensus Estimate.
“We continue to benefit from the strong industry environment, improved market dynamics and new opportunities in our core business and expanding portfolio. In parallel, we remain focused on further enhancing exposure and alignment to several other meaningful near and long-term opportunities.”

MTSI

M/A-COM Tech: Stifel sees downside reaction as overdone; tgt cut to $57 from $64 (61.06)
Stifel notes that MTSI is indicated down over 20% and they believe the reaction is overdone. Firm says while MACOM continues to cite many opportunities that support its long-term target model, the near-term continues to be impacted by weakness out of China, which is causing significant headwinds to its PON, long-haul/metro and backhaul/OTN businesses. Despite this persistent cyclical weakness, the firm is however encouraged by the strength outside of China, especially in Japan and No. America and in particular its Data Center business, which continues to exceed expectations and is poised for further growth. They also highlight several other strategic and secular growth opportunities still yet to ramp meaningfully (GaN, 100G, Active Antenna and DC), which helps support its ability to achieve its target model of ~20% growth in FY18, with improving GMs and overall profitability. Firm cuts their tgt to $57 from $64.

I am heading out now. But what you want to pay attention to next is the application software sector. It is weak today and not looking sporty. Should that sector fail, the entire market will follow suit — just like in early 2014.

Here’s a look at the semis.

Regarding the application software sector, keep a close eye on CRM, WDAY, SHOP, VEEV and DATA.

UPDATE: I found a note I left in Exodus, dated 10/7/10. You can go see for yourselves what that warning did to the semis that day.

All of the dollarfags were rejoicing after the election — as the dollar roared higher alongside the market. It made no sense to see this, since we’re largely reliant upon exports to further our financial hegemony.

Lo and behold, after Trump talked the dollar down — praising the undervalued nature of the euro back in January — the dollar has been on a ruinous path to hell.

Here’s the US dollar index.

And here is the Euro crushing the souls and the American spirit, embedded in the US dollar.

A weaker dollar is supposed to promote greater exports — and stronger commodities. Thus far, we haven’t seen the silver lining of all this dollar chicanery, only the onerous effects it imposes on the aristocracy as they saunter overseas for their summer vacations.